DSIP (Delta sleep-inducing peptide)

Synonyms: Sleep inducing peptide;Waggdasge;Trp-ala-gly-gly-asn-ala-ser-gly-glu;Trp-ala-gly-gly-asp-ala-ser-gly-glu;Trp-ala-gly-gly-asp-ala-ser-gly-glu 4h2o;Delta sleep inducing peptide;Delta sleep-inducing peptide 4h2o;Dsip

CAS: 62568-57-4 

MF: C35H48N10O15 

MW: 848.81 

Product Categories: Peptide 

Delta sleep-inducing peptide alters bispectral index, the electroencephalogram and heart rate variability when used as an adjunct to isoflurane anaesthesia.

Delta sleep-inducing peptide, abbreviated DSIP, is a neuropeptide that when infused into the mesodiencephalic ventricle of recipient rabbits induces spindle and delta EEG activity and reduced motor activities.

Delta sleep-inducing peptide was first discovered in 1974 by the Swiss Schoenenberger-Monnier group who isolated it from the cerebral venous blood of rabbits in an induced state of sleep. It was primarily believed to be involved in sleep regulation due to its apparent ability to induce slow-wave sleep in rabbits, but studies on the subject have been contradictory.

DSIP is an amphiphilic peptide of molecular weight 850 daltons with the amino acid motif:

N-Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu-C