Tamoxifen Citrate (Nolvadex)
Chemical Name: (Z)-2-[4-(1,2-Diphenyl-1-butenyl)phenoxyl]-N,N-dimethyl-ethanamine-citrate;
1-p-beta-Dimethylaminoethoxyphenyl-trans-1,2-diphenylbut-1-ene citrate
Molecular Formula: C26H29NO.C6H8O7
Molecular weight: 563.64
CAS NO.: 54965-24-1
Appearance: white crystalline powder ; MP: 140-144 ºC
Standard: CP/2000; USP/26
Chemical Properties:white to off-white powder
Usage:estrogen antagonist, antineoplastic ,sage anti-estrogen, protein kinase C inhibitor, beneficial cardiovascular effects, bone cancer treatment, induces DNA adduct formation .
Tamoxifen Citrate (Nolvadex) Application:
Antitumor drugs raw material, suitable for breast cancer.It is not correct that Nolvadex reduces levels of estrogen: rather, it blocks estrogen from estrogen receptors and, in those tissuses .where it is an antagonist, causes the receptor to do nothing. Nolvadex is not an anabolic steroidbut is used to manage side effects from steroids. Tamoxifen Citrate (Nolvadex) Application:
Tamoxifen Citrate (Nolvadex) COA:
Appearance White crystalline powder
Identification IR , UV conform Conform
Loss on drying min5ml 0.21ml
Residue on ignition Not more than 0.2% 0.06ml
Iron Not more than 0.005% 0.0018%
Heavy metals Not more than 0.001% 0.0006%
Related substances Total: Not more than 1.0%
Individual: Not more than 0.5% 0.32%
0.14%
E-isomer Not more than 0.3% 0.19%
Organic volatile impurities Conforms Conforms
Assay 99.0~101.0% 99.51%