Trilostane

Synonyms: (2-alpha,4-alpha,5-alpha,17-beta)-4,5-epoxy-17-hydroxy-3-oxoandrostane-2-car;17-beta)-ph;4-alpha,5-epoxy-17-beta-hydroxy-3-oxo-5-alpha-androstane-2-alpha-carbonitril;4-alpha,5-epoxy-3,17-dihydroxy-5-alpha-androst-2-ene-2-carbonitrile;4-alpha-5-epoxy-17-beta-hydroxy-3-oxo-5-alpha-androstane-2-alpha-carbonitril

CAS: 13647-35-3 

MF: C20H27NO3 

MW: 329.43 

EINECS: 237-133-0 

Product Categories: Intermediates & Fine Chemicals;Pharmaceuticals;Steroids;Inhibitor

Chemical Properties: Tan Crystals 

Usage: An inhibitor of steroid biosynthesis. Used as an adrenocortical suppressant. Used in the treatment of breast cancer . antifungal, inhibits mitosis in metaphase .

Packing:1kg/foil bag or as  required

 Trilostane  COA:

Test Items Specification Test Results

 Appearance white oralmost white,crystalline powder Conform

 Solubility Freely soluble in water,practically insoluble or very slightly soluble in alcohol and in methylene chloride. Conform

 Identification A The UV absorption spectrum of the sample shows an absorption maximum at 276nm.The specific absorbance at the Maximum is55 to 64. Conform

B Infraed absorption spectrophotometry. Conform

C Chromatogram obtained with test solution (b) is similar in position color & size to the principal spot in the chromatogram obtained with the reference solution. Conform

D An orange-red color develop in methylene chloride layer. Conform

E It geves reaction (a) of sulphates. Conform

 Appearance of solution Solution S is clear and not more intensely coloured than reference solution in BY6. Conform

 Optical rotation negative 0.10° to +0.10°determined on solution S. +0.01°

 Acidity or alkalinity NMT 0.4ml of 0.01M HCL is required to change the color of the indicator to red. Conform

 Related substances Impurity J ≤0.20% Conform

Any other impurity ≤0.30% Conform

Total impurity ≤1.0% Conform

 Boron ≤50ppm Conform

 Sulphated ash ≤0.10% 0.06%

 Loss on drying ≤0.5% 0.30%

 Assay(on dried basis) 98.0~101.0% 99.5%