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Basic info.
CAS No.77591-33-4:
Molecular Formula: C212H350N56O78S
Molecular Weight: 4963.49
Purity (HPLC): 99.5%min
Single Impurity (HPLC): 2.0%max
Amino Acid Composition: ± 10% of theoretical
Peptide Content (N%): ≥ 80.0%
Water Content(Karl Fischer): ≤ 5.0%
Acetate Content (HPIC): ≤ 15.0%
MS(ESI): Consistent
Mass Balance: 95.0~105.0%
Appearance: White powder
Description:
TB-500 is a synthetic fraction of the protein thymosin beta-4, which is present in virtually all human and animal cells. The main purpose of this peptide is to promote healing. It also promotes creation of new blood and muscle cells. The healing effects of TB-500 have been observed in tendons, ligaments, muscle, skin, heart, and the eyes. Thymosin beta-4 is naturally produced in higher concentration where tissue has been damaged. This peptide is also a very potent anti-inflamatory agent.
TB-500 is different from other repair factors, because it promotes endothelial and keratinocyte migration. It also does not bind to the extracellular matrix and has a very low molecular weight. Because of this it can travel long distances through the tissues in the human body.
One of TB-500 key mechanisms of action is its ability to regulate the cell-building protein - Actin. Of the thousands of proteins present within human cells, actin represents roughly 10% of the total. It is thus a vital component of cell structure and movement.
Application:
1.TB-500 is typically provided as lyophilized (freeze-dried) powder in vials of 2.0 mg. A convenient amount of sterile or bacteriostatic water will be added, such as 1.0 mL. In the most common dosing protocol, the entire vial is taken at one time. If taking the entire vial, the entire amount will be drawn into a syringe, typically an insulin syringe, and injected. Injection may be subcutaneous, intramuscular, or intravenous, according to personal preference.
2.The most common dosing protocol is to take 2.0 or 2.5 mg of TB-500 twice per week for four to six weeks, and then reduce to a lower dosing rate such as once or twice per month for maintenance.The body of knowledge is as yet limited with regard to TB-500 dosage. The above protocol may or may not be the most efficient, but it is the protocol with the most track record. It's entirely possible that as knowledge is gained, method of use will change. A reasonable possibility, for example, is to increase dosing frequency to 3x/week (which I have done personally to good effect), or to increase dosing to 4 or 5 mg twice per week. Before going to such a program, however, I recommend trying the standard protocol first.
3.If interested in animal uses, a typical dosing protocol for horses is a course of six 10 mg injections at 7-10 day intervals. For more intensive treatment, 20 mg is used weekly. For racing dogs, a typical protocol is a course of six 5 mg injections taken weekly.
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