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Product Name:Alendronate Sodium
CAS: 121268-17-5
MF: C4H12NO7P2.Na.3H2O
MW: 325.12
Assay: 99.5%
Appearance: White powder
Product Categories: Miscellaneous Biochemicals;All Inhibitors;Osteoporosis;
Inhibitors;Intermediates & Fine Chemicals;Pharmaceuticals;Miscellaneous Compounds;Phosphorylating and Phosphitylating Agents;REQUIP
Synonyms: G-704650;ALENDRONATE SODIUM SALT;ALENDRONATE, SODIUM SALT TRIHYDRATE;ALENDRONATE SODIUM TRIHYDRATE;ALENDRONNATE SODIUM TRIHYDRATE;ALENDRONIC ACID, MONOSODIUM SALT, TRIHYDRATE;ADRONAT;4-AMINO-1-HYDROXYBUTYLIDINE-1,1-BISPHOSPHONATE SODIUM SALT TRIHYDRATE
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Product Name |
Alendronate Sodium |
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CAS |
121268-17-5 |
|
MF |
C4H12NO7P2.Na.3H2O |
|
MW |
325.12 |
|
Assay |
99.5% |
|
Appearance |
White Crystalline Solid |
|
Categories |
Miscellaneous Biochemicals;All Inhibitors;Osteoporosis;Inhibitors; Intermediates & Fine Chemicals;Pharmaceuticals;Miscellaneous Compounds;Phosphorylating and Phosphitylating Agents;REQUIP |
|
Synonyms |
G-704650;ALENDRONATE SODIUM SALT;ALENDRONATE, SODIUM SALT TRIHYDRATE;ALENDRONATE SODIUM TRIHYDRATE;ALENDRONNATE SODIUM TRIHYDRATE; ALENDRONIC ACID, MONOSODIUM SALT, TRIHYDRATE; ADRONAT;4-AMINO-1-HYDROXYBUTYLIDINE-1,1-BISPHOSPHONATE SODIUM SALT TRIHYDRATE |
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Usage |
A bisphosphonate used as a bone reabsoption inhibitor ; dopamine receptor agonist, antiParkinsonian |
Description :
Alendronate sodium is a farnesyl diphosphate synthase inhibitor with IC50 of 460 nM. It is a nitrogen-containing bisphosphate that acts as a robust inhibitor of bone resorption and induces apoptosis in osteoclasts.
It causes disruption of the ruffled border and actin cytoskeleton of osteoclasts and induces in vitro apoptosis of osteoclasts and macrophages by inhibiting farnesyl diphosphate synthase (IC50 = 460 nM).
