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Quick Detail :
Trilostane
Synonym: Vetoryl; 17-hydroxy-3-oxo-4,5-epoxyandrostane-2-carbonitrile; (4alpha,5alpha,17beta)-3,17-dihydroxy-4,5-epoxyandrost-2-ene-2-carbonitrile
CAS Registry Number: 13647-35-3
MF: C20H27NO3
MW: 329.43
MS:
Alias: 99%
Einecs No: 237-133-0
Grade : Pharmaceutical Grade
Storage: Shading, confined preservation
Appearance:: White crystalline powder
Manufacturer : NJBN STEROID
Usage : Trilostane can inhibit cortical hormone in the process of synthesis of 3 beta dehydrogenase, make the cortisol, aldosterone synthesis decreased, clinically used in the treatment of Cushing syndrome (hypercortisolism) and primary aldosteronism. This product also had significantly effect to decreased serum testosterone level.
Application :
Evista (Raloxifene hydrochloride) is an estrogen agonist / antagonist, referred to as a Selective estrogen receptor modulator (SERMs) and belongs to the benzothiophene class of compounds. The biological actions of Raloxifene are largely settlement through binding to estrogen receptors. This binding results in the activation of Pathways to estrogenic in some tissues (agonists) and and the Blockade of estrogenic Foundation in other tissues (the antagonist). The agonistic or antagonistic activity of raloxiffene depends on the extent of the recruitment of coactivators and corepressors to the estrogen receptor (ER), the promoter of the target gene. Raloxifene appears to act as an estrogen agonist in bone. It decreases bone resorptive and bone Turnovo, increases bone mineral density and decreases fracture incidence.
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