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Avanafil
Assay: 99% min;
CAS: 330784-47-9 ;
Molecular Formula: C23H26ClN7O3 ;
Molecular Weight: 483.9506 ;
Character: White to Off-White Cyrstalline Solid ;
Usage: Used for the treatment of erectile dysfunction. A phosphodiesterase 5 inhibitor ;
Categories: Active Pharmaceutical Ingredients; Cnbio; Erectile Dysfunction; Inhibitors; Intermediates & Fine Chemicals; Pharmaceuticals; API's.
Description:
Avanafil is a PDE5 inhibitor approved for erectile dysfunction by the FDA on April 27, 2012 and by EMA on June 21, 2013.
Avanafil is known by the trademark names Stendra and Spedra and was developed by Vivus Inc.In July 2013 Vivus announced partnership with Menarini Group, which will commercialise and promote Spedra in over 40 European countries plus Australia and New Zealand.
Avanafil acts by inhibiting a specific phosphodiesterase type 5 enzyme which is found in various body tissues, but primarily in the corpus cavernosum penis, as well as the retina. Other similar drugs are sildenafil, tadalafil and vardenafil. The advantage of avanafil is that it has very fast onset of action compared with other PDE5 inhibitors. It is absorbed quickly, reaching a maximum concentration in about 30–45 minutes. about two-thirds of the participants were able to engage in sexual activity within 15 minutes.
Usage:
Avanafil can be an oral drug which is used regarding treating erection problems (the shortcoming to obtain or sustain a male member erection), also referred to as erectile malfunction (MALE IMPOTENCE). It really is in any class regarding drugs referred to as phosphodiesterase inhibitors in which also contains tadalafil (Cialis), sildenafil (Viagra) and also vardenafil (Levitra).
Avanafil works by preventing the action of a chemical in your body, called phosphodiesterase type-5. This helps to widen (relax) blood vessels and improves the flow of blood to the penis following sexual stimulation. This helps to maintain an erection.
How to Take This Medicine
DOSING: For some individuals, the advised starting serving of avanafil will be 100 mg each day taken about thirty minutes before sex. Depending around the adequacy with the response or negative effects, the dose could be increased to be able to 200 mg or perhaps decreased to be able to 50 mg per day. Individuals that are taking drugs that moderately raise the blood numbers of avanafil must not exceed a complete dose regarding 50 mg in a day (Notice drug connections).
The serving of avanafil must not exceed 50 mg everyday when along with verapamil (Calan) due to the fact these medicine moderately boost blood numbers of avanafil.
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