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Dutasteride (Avodart)
English Synonyms: (5alpha,17beta)-n-{2,5-bis(trifluoromethyl)phenyl}-3-oxo-4-azaandrost-l-ene-17-carboxamide;DUTASTERIDE;GG-745, GI-198745,;5alpha,17beta)-N-[2,5-Bis(trifluoromethyl)phenyl]-3-oxo-4- Aza -androst-1-ene-17-carboxamide;Duagen;(5a,17)-N-[2,5-Bis(trifluoromethyl)phenyl]-3-oxo-4-azaandrost-1-ene-17-carboxamide;Avodart;GI 198745;
CAS NO.: 164656-23-9 ;
Assay: 99% ;
Molecular Formula:C27H30F6N2O2 ;
Molecular Weight:528.53 ;
Packing:1kg/tin/foil bag ;
Standard: Enterprise ;
Appearance: White or almost white crystalline powder ;
Usage: Prostate enlargement, male pattern hair loss, seborrheic alopecia, hereditary hair loss.
Description:
Dutasteride (INN, USAN, BAN, JAN) (brand name Avodart), developed by GlaxoSmithKline, is a triple 5 alpha-reductase inhibitor that inhibits conversion of testosterone to dihydrotestosterone (DHT). It is used to treat benign prostatic hyperplasia. It increases the risk of erectile dysfunction and decreased sexual desire.
Usage:
Dutasteride is the first and the only dual 5 alpha reductase inhibitor to be used in the treatment of prostatic hyperplasia. It can improve urinary system symptom, reduce the onset of acute urinary retention and the risk of prostate surgery. Tamsulosin is alpha receptor blockers. It can improve the symptom of prostate hyperplasia.
Dutasteride is useful for treating benign prostatic hyperplasia (BPH); colloquially known as an "enlarged prostate".
In those who are being regularly screened, 5 alpha-reductase inhibitors such as finasteride and dutasteride reduce the overall risk of being diagnosed with prostate cancer; however, there is insufficient data to determine if they have an effect on the risk of death and may increase the chance of more serious cases.
Application:
Dutasteride, at 2.5mgs/day is roughly 1.5X more effective than Finasteride at 5mgs/day, at treating hair loss (both halting it as well as regrowing it). In addition, Dutasteride can be used successfully at that same dose to treat prostate enlargement, and a lesser known effect of Dutasteride (again, at that same dose) use is to treat Acne caused by an overabundance of androgens in the body.
For the steroid using athlete suffering from DHT-related side effects, Dutasteride may be the answer. Hairloss, Acne, and prostate growth can all (potentially) be completely halted with the use of this product. Unfortunately, DHT is not all bad, and you potentially lose some muscle hardness (an amorphous quality if ever there is one), and even some of the other qualities we like from our androgen use.
Alsosince this only prevents the 5A-reduction of the androgens subject to that conversion into a dihydro form of themit will likely do nothing to stop hairloss or other symptoms caused entirely by the use of the androgens in the DHT family.
