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English Synonyms: decadronphosphate;dexadreson;dexagro;dexamethasonedisodiumphosphate;disodiumdexamethasonephosphate;disodiumsalt,(11beta,16alpha)-y);megacort;pregna-1,4-diene-3,20-dione,9-fluoro-11,17-dihydroxy-16-methyl-21-(phosphonoox
CAS NO.: 2392-39-4
EINECS: 219-243-0
Assay: 99%
Molecular Formula: C22H28FNa2O8P
Molecular Weight: 516.4
Quality Standard: CP2002/CP2005/USP/BP/EP
Packing:1kg/tin,5kg/tin
Appearance: White to white crystalline powder
Usage: This product adrenal cortex hormone class medicine. Have anti-inflammatory, anti-allergic and immunosuppressive pharmacological effects and other.
2.Description:
Dexamethasone 21-phosphate disodium salt is a system glucocorticoid with anti-inflammatory properties. Dexamethasone 21-phosphate disodium salt is the pro-drug, which is converted to dexamethasone. It stimulates uptake of glutamine in the cerebral cortex and induces apoptosis. Additionally, it is an inhibitor of the sodium phosphate symporter and GR activator.
3. Medical Uses
This is an anti-inflammatory glucocorticoid and corticosteroid. It is used in the treatment of hypertensionI, in eye and ear preparations and in systemic preparations. It is administered by injection, by inhalation, or applied to the skin and conjunctiva. Further research may identify additional product or industrial usages of this chemical.
4.Technical Test Sheet
|
Product name |
Dexamethasone 21-phosphate disodium salt |
|
|
Appearance |
White crystalline powder |
|
|
Chromatographic purity |
Any individual impurity not more than 1.0% Total impurities not more than 2.0% |
0.35% 0.8% |
|
Loss on drying |
Not more than 0.5% |
0.12% |
|
Residue on ignition |
Not more than 0.2% |
0.05% |
|
Residual solvents |
Methanol≤3000ppm Methylene Chloride≤600ppm Chloroform≤60ppm Tetrahydrofuran≤720ppm |
356ppm Not detect out Not detect out Not detect out |
|
Assay |
Between 97.0% and 102.0% |
98.5% |
|
Micronixation |
90% not more than 10 microns |
90% not more than 10 aicrons |
