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Octyl methoxycinnamate
Applications:Octyl methoxycinnamate (INCI) or octinoxate (USAN), trade names Eusolex 2292 and Uvinul MC80, is an organic compound that is an ingredient in some sunscreens and lip balms. It is an ester formed from methoxycinnamic acid and 2-ethylhexanol. It is a clear liquid that is insoluble in water.
Its primary use is in suncreens and other cosmetics to absorb UV-B and UV-A rays from the sun, protecting the skin from damage. It is also used to reduce the appearance of scars.
One study performed in 2000 raised safety concerns about octyl methoxycinnamate by demonstrating toxicity to mouse cells at concentrations lower than typical levels in sunscreens.[2] However, a more recent study concluded that octyl methoxycinnamate and other sun screening agents do not penetrate the outer skin in sufficient concentration to cause any significant toxicity to the underlying human keratinocytes.[3] Estrogenic effects were noted in laboratory animals at concentrations close to those experienced by sunscreen users.[4][dead link][5] A study published in 2011 explored the effects of pre- and post-natal exposure to high doses of octyl methoxycinnamate in rats and showed, for example, that the testes weight and testoserone levels were significantly reduced in male rats.[6]
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