Closantel sodium

Chinese Name: Sodium cyanoiodosalamide
Chinese alias: zinc pyrithione. zinc thiopyridine
English Name: Closantel sodium
CAS No. 61438-64-0
Molecular formula: C23H15Cl2I2N2NaO4
Molecular weight: 731.08100
Precise quality: 729.84000
PSA: 113.25000
LogP: 4.51228

Physicochemical properties
Melting point: > 230 C (dec.)
Boiling point: 590.5 C at 760 mmHg
Flash point: 310.9 C
Storage condition: Refrigerator

Purpose:
1. Sodium cyanosalamide is a broad-spectrum insecticide, which has good effect on many kinds of trematodes, nematodes and arthropods larvae. Its anti-trematode activity is mainly directed against Fasciola hepatica, while its anti-nematode and anti-arthropods larvae are mainly directed against various blood or plasma-feeding worms.

2. This product is widely used in cattle and sheep for various infections of the above parasitic diseases. It can be administered orally or non-intestinally (subcutaneously or intramuscularly), and has therapeutic and preventive effects. There are injections, pills and soaking agents on the market. In general, the compound soaking agent is prepared with toluimidazole and other benzimidazole products, which is used in sheep body, and the compound pill is made with levamisole, which is used in cattle body.

3. As an antiparasitic agent, it is a strong oxidative phosphorylation uncoupling agent, which can inhibit the phosphorylation process of mitochondria, thus preventing the synthesis of adenosine triphosphate (ATP) in the parasite, resulting in the rapid decrease of energy metabolism activity and eventual death of the parasite.


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