Paclitaxel CAS NO：33069-62-4

Paclitaxel
Product Name:paclitaxel
Another Name:5 β, 20- epoxy -1, 2 α, 4β, 7β, 10α, 13 - six hydroxyl taxane -11- allyl -9- ketone -4, 10- two acetate -2- benzoate -13[ ( 2 ' R, 3 ' S ) -N- benzoyl -3- phenylisoserine ester
Molecular Weight:853.92
Molecular Formula:C47H51NO14
CAS NO：33069-62-4
[ source ] products is the dried root of Taxus plants of Taxus, leaves and bark.
[ size ] 99.5% content
[ physical ] white crystal powder. Odorless, tasteless. Insoluble in water, soluble in chloroform, acetone and other organic solvents.
Function: through the clinical study ofⅡ - Ⅲ, paclitaxel is mainly suitable for ovarian cancer and breast cancer, lung cancer, colorectal cancer, melanoma, head and neck cancer, lymphoma, brain tumors have certain curative effect.

Characters
A white crystalline powder, odorless, tasteless
Solubility
Dissolved in methanol, ethanol or chloroform, slightly soluble in ether, insoluble in water.
Optical rotation -48o~-56o  Identification
UV:Should have a maximum
absorption at 227nm wavelength
HPLC:Paclitaxel peak retention time and standard control retention time should be consistent
Solution appearance Clear and colorless 
Related impurities
7-Epitaxol  ≤ 0.5%   
Deacetyltaxol   ≤0.5% 
Single unknown impurity   ≤0.1% 
Other total impurities ≤1.5% 
Solvent Residue
Methanol      ≤3000ppm  
Methyl cyanide    ≤410ppm
Acetone      ≤5000ppm 
Methylene chloride  ≤600ppm
Chloroform    ≤60ppm 
Loss on drying  ≤1.0% 
Assay    98.0%~102.0%  
Heavy metal    ≤ 20ppm 
Bacterial
endotoxins    ≤0.4 EU/mg