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Cialis(Tadalafil) Profile
Tadalafil is PDE5 inhibitor marketed in pill form for treating erectile dysfunction (ED) under
the name .
Cialis, and under the name Adcirca for the treatment of pulmonary arterial hypertension. In
October 2011 the U.S. Food and Drug Administration (FDA) approved Cialis for treating the signs
and symptoms of benign prostatic hyperplasia (BPH) as well as a combination of BPH and erectile dysfunction (ED when the conditions coincide. It initially was developed by the biotechnology
company ICOS, and then again developed and marketed world-wide by Lilly ICOS, LLC, the joint venture of ICOS Corporation and Eli Lilly and Company. Cialistablets, in 2.5 mg, 5 mg, 10 mg, and 20 mg doses, are yellow, film-coated, and almond-shaped. The approved dose for pulmonary
arterial hypertension is 40 mg (two 20-mg tablets) once daily.
Tadalafil is also manufactured and sold under the name of Tadacip by the Indian pharmaceutical company Cipla in doses of 10 mg and 20 mg.
On November 21, 2003 the FDA approved tadalafil (as Cialis) for sale in the United States as
the third ED prescription drug pill (after sildenafil citrate (Viagra) and vardenafil (Levitra)).
Like sildenafil and vardenafil, tadalafil is recommended as an 'as needed' medication. Cialis is
the only one of the three that is also offered as a once-daily medication.
Moreover, tadalafil was approved in May 2009 in the United States for the treatment of
pulmonary arterial hypertension and is under regulatory review in other regions for this condition.
In late November 2008,Eli Lilly sold the exclusive rights to commercialize tadalafil for pulmonary arterial hypertension in the United States to United Therapeutics for an upfront payment of
$150 million.
Product Name | Cialis(Tadalafil)
|
CAS Number |
171596-29-5
|
Molecular formula |
C22H19N3O4
|
Molecular weight |
389.4
|
Molecular structure | |
Melting point | 187-189°C |
Assays |
99%
|
Appearance |
White or nearly white crystalline powder
|
Product uses |
Phosphodiesterase 5 inhibitors, for the treatment of male erectile dysfunction
|
storage | Shading, confined preservation. |