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CAS: 120511-73-1
M.F.: C17H19N5
M.W: 293.37
Appearance: White crystalline powder
Identification: IR, HPLC, Reactive: positive
Solubility: Freely soluble in methanol, acetone, ethanol and tetrahydrofuran. Easily soluble in acetonitrile.
Related Substance: Total Impurities: 0.5% max.
Total Unspecified Impurity: 0.2% max.
Any individual unknown impurity: 0.1% max.
Related compound B: 0.2% max.
Related compound C: 0.2% max.
Related compound D: 0.1% max.
Related compound E: 0.1% max.
Limit of Cyclohexane: 0.08% max.
Limit of Ethylacetate: 0.1% max.
Melting point: 81.0°C ~ 84.0°C
Loss on Drying: 0.3% max.
Residue on Ignition: 0.1% max.
Heavy metals: 0.001% max.
Assay (by HPLC): 98.0% ~ 102.0%
Standard: USP36
Details: Arimidex (anastrozole) is the aromatase inhibitor of choice. Arimidex’s mechanism of action - blocking conversion of aromatizable steroids to estrogen - is in contrast to the mechanism of action of anti-estrogens such as clomiphene (Clomid) or tamoxifen (Nolvadex), which block estrogen receptors in some tissues, and activate estrogen receptors in others.
