Diuretic powder Spironolactone

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Brand: SMQ
型号: 52-01-7
规格: White or almost white crystalline powder
Price: 5.00USD/g
Min.Order: 10 g
Supply 1000 g
Delivery: Shipment within 3 days since the date of payment
Address: China
Valid until: 2035-10-10
Updated on: 2016-01-11 11:55
Hits: 1226306
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Spironolactone

Prodcut name: Spironolactone

Synonym: Aldactone;Antisterone;spirolactone;7-alpha-Acetylthio-3-oxo-17-alpha-pregn-4-ene-21,17-beta- carbolactone

CAS Registry Number: 52-01-7

Assay: 97.0%~103.0%

Packaging: 1kg/foil bag

Molecular Formula: C24H32O4S

Molecular Weight: 416.5735

Appearance: White or almost white fine crystalline powder;Slightly bitter taste, odourless or slightly mercaptan odor.Insoluble in water, soluble in ethanol, soluble in benzene or ethyl acetate.

Description:

 

It is a synthetic, steroidal antimineralocorticoid and antiandrogen that also has some weak progestogen properties, as well as some indirect estrogen and glucocorticoid effects. It is used primarily as a diuretic and antihypertensive, but may also be employed for the purpose of reducing elevated or unwanted androgen activity in the body.It acts predominantly as an antagonist of the mineralocorticoid (or aldosterone) and androgen receptors, and in relation to its antimineralocorticoid effects, belongs to a class of pharmaceutical drugs known as potassium-sparing diuretics.
Applications:

 

Spironolactone is competitive inhibition of aldosterone drugs, drug itself is not active, role is diuresis and endogenous competitive aldosterone antagonist and happen, belongs to the potassium diuretics.

 

Specifications:

 

Test Items

Specification

Test Results

Appearance

Almost white crystalline powder

Almost white crystalline powder

Identification

Meet the requirements

Meet the requirements

Melting range

198℃~209

Between 198 and 209

205.0℃~207.0

Specific rotation

-33°~-37°

Between -33° and -37°

-35°

Loss on drying

≤0.5%

Not more than 0.5%

0.2%

Limit of mercapto compounds

Meet the requirements

Meet the requirements

Ordinary impurities

Meet the requirements

Meet the requirements

Organic volatile impurities

Meet the requirements

Meet the requirements

Assay(on the dried basis)

97.0%~103.0%(C24H32O4S)

Between 97.0% and 103.0%

98.99%

Conclusion

Meet the requirements of USP29

 

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